Recombinant Claudin 18.2 Monoclonal Antibody
Product Specifications
Background
Claudin 18 (CLDN18) belongs to the large claudin family of proteins, which are tetraspan transmembrane proteins of tight junctions. Claudins exhibit specific patterns of expression in different tissues. CLDN18 is specifically expressed in the stomach and lung. CLDN18 has two alternatively spliced variants, CLDN18.1 and CLDN18.2. CLDN18.2 is a highly selective gastric lineage marker that determines the gastric phenotype in a neoplastic condition, whereas CLDN18.1 is lung specific. Altered CLDN18 expression has been reported in various human malignancies, including gastric cancer, lung adenocarcinoma, and pancreatic neoplasm.
Abbreviation
Claudin 18.2
UniProt
P56856
Host
Rabbit
Reactivity
Human; Rat; Mouse
Immunogen
Recombinant human Claudin 18.2 fragment
Target
UNQ; PRO; CLDN; SFTA; Claudin; Claudin-; CLDN18; SFTA5; SFTPJ; Claudin-18; Claudin-18.2; UNQ778; PRO1572; SPJ
Clonality
Monoclonal,Recombinant
Clone
A543
Conjugation
Unconjugated
Applications
IHC
Field of Research
Signal Transduction
Purification
Protein A purified
Concentration
1 mg/mL
Dilution
IHC 1∶200-1∶1000
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Isotype
IgG, κ
Available Sizes
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