Bortezomib
Product Specifications
CAS Number
179324-69-7
Synonyms
LDP-341, MLM341, NSC 681239, PS-341, BTZ
Target
Proteasome
Applications
Proteases
Smiles
B (C (CC (C) C) NC (=O) C (CC1=CC=CC=C1) NC (=O) C2=NC=CN=C2) (O) O
Molecular Formula
C19H25BN4O4
Additionnal Information
Bortezomib is a potent 20S proteasome inhibitor with Ki of 0.6 nM. It exhibits favorable selectivity towards tumor cells over normal cells. Bortezomib (PS-341) inhibits NF-κB and induces ERK phosphorylation to suppress cathepsin B and inhibit the catalytic process of autophagy in ovarian cancer and other solid tumors.
Storage Conditions
3 years -20°C (in the dark) powder1 year -80°C (in the dark) in solvent
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