Protein kinase inhibitor 5

Protein kinase inhibitor 5 is a potent TRK-A inhibitor with an IC50 value of 1.8 nM. Protein kinase inhibitor 5 inhibits cell viability[1].

Product Specifications

CAS Number

[2278204-94-5]

UNSPSC

12352005

Target

Trk Receptor

Type

Reference compound

Related Pathways

Neuronal Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/protein-kinase-inhibitor-5.html

Solubility

10 mM in DMSO

Smiles

O=C(NC1=C2N=C(N3[C@@H](C4=CC(F)=CC=C4F)CCC3)C=CN2N=C1)C5=CC=C(CN6CCN(C)CC6)C=C5

Molecular Formula

C29H31F2N7O

Molecular Weight

531.60

References & Citations

[1]Dawei Zhang, et al. Substituted pyrazolopyrimidines useful as kinases inhibitors. WO2019029629A1.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

TrkA

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