Ponatinib hydrochloride
Product Specifications
CAS Number
1114544-31-8
Synonyms
AP24534 hydrochloride
Target
Bcr-Abl
Applications
Protein Tyrosine Kinase
Molecular Formula
C29H27F3N6O.ClH
Additionnal Information
Ponatinib hydrochloride is a potent, orally available multi-targeted inhibitor of Pan BCR-ABL kinase. It potently inhibits ABL with an IC50 of 0.37 nM, also inhibits SRC , VEGFR2, FGFR1, PDGFRα, LYN with an IC50s of 5.4 nM, 1.5 nM, 2.2 nM, 1.1 nM, 0.24 nM respectively and exhibits significant potential in cancer reserach.
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