KRAS-533
Product Specifications
CAS Number
10161-87-2
Target
Ras
Applications
Apoptosis
Molecular Formula
C13H16BrNO3
Additionnal Information
KRAS-533 is a potent agonist of KRAS that binds to the GTP/GDP-binding pocket and prevents the hydrolysis of GTP, leading to accumulation of active GTP-bound KRAS. This triggers both apoptotic and autophagic cell death pathways in cancer cells, leading to potent suppression of mutant KRAS lung cancer in vitro and in animal models.
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