Ac-[Pro18, Asp21]-Beta-Amyloid (17-21) amide
Peptide to Ac-[Pro18, Asp21]-Beta-Amyloid (17-21) amide
Product Specifications
CAS Number
339990-02-2
Structure Composition
Ac-Leu-Pro-Phe-Phe-Asp-NH2
Applications
The pentapeptide Ac-LPFFD-NH2 (iAβ5p) is an analog of product [Pro18, Asp21]-Beta-Amyloid (17-21) with small chemical modifications which enhance its stability against proteolytic degradation. iAβ5p acts as a β-sheet breaker peptide and crosses the blood-brain barrier at a higher rate than most proteins and peptides known to be selectively taken up by the brain so that it is assumed that the peptide is being specifically transported to the brain. A significant increase in neuronal survival and decrease in brain inflammation associated with the reduction of amyloid plaques in two different transgenic Alzheimer`s disease (AD) models is additionally reported for iAβ5p.
Purity
> 95%
Form
Lyophilized powder
Molecular Formula
C35H46N6O8
Molecular Weight
678.79
Storage Conditions
Shipped at 4°C. Store at -20°C for one year.
Light Source
Synthetic
Available Sizes
Frequently Asked Questions
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