(S) -WAY 100135 (dihydrochloride)

(S) -WAY 100135 dihydrochloride is a highly selective and potent antagonist of 5-HT 1A (IC50=33.9 nM) . (S) -WAY 100135 dihydrochloride has anxiolytic activity in animal models[1].

Product Specifications

CAS Number

[149007-54-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/s-way-100135-dihydrochloride.html

Solubility

10 mM in DMSO

Smiles

COC1=C(N2CCN(CC2)C[C@H](C3=CC=CC=C3)C(NC(C)(C)C)=O)C=CC=C1.Cl.Cl

Molecular Formula

C24H35Cl2N3O2

Molecular Weight

468.46

Precautions

H302, H315, H319, H335

References & Citations

[1]Cliffe IA, et al. (S) -N-tert-butyl-3- (4- (2-methoxyphenyl) -piperazin-1-yl) -2-phenylpropanamide [ (S) -WAY-100135]: a selective antagonist at presynaptic and postsynaptic 5-HT1A receptors. J Med Chem. 1993 May 14;36 (10) :1509-10.