KillerTRAILTM Protein (soluble) (human), (recombinant) (BULK)
Product Specifications
Specifications
ED 50 : 20ng/ml (BJAB cells)
Product Name Alternative
Apo-2L, TNFSF 10, CD253
Certification
RUO
UniProt
P50591
Source
Produced in E. coli . The extracellular domain of human TRAIL (aa 95-281) is fused at the N-terminus to a His-tag and a linker peptide.
Purification
Affinity purified.
Endotoxin
<10EU/μg protein (LAL test; Bio Whittaker) .
Purity
≥98% (SDS-PAGE)
Activity
Induces apoptosis in a concentration range of 10-100ng/ml. Note: This protein does not require a cross-linking enhancer for its potent biological activity. For cell lines that require extensive cross-linking of the TRAIL-Rs for killing (e.g. Jurkat) use SUPERKILLERTRAIL ® (Prod. No. ALX-201-115) .
Reconstitution
For a special storage and dilution buffer see KillerTRAILTM Storage and Dilution Buffer (Prod. No. ALX-505-005) .
Shipping Conditions
Dry Ice
Storage Conditions
-80°C
Specificity
Binds to human and mouse TRAIL receptors and osteoprotegerin (OPG) .
Formulation
Liquid. In 20mM HEPES, pH 7.4, containing 150mM sodium chloride, 0.005% Tween 20, 1% sucrose, 1mM DTT.
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