C-hexaAMP

C-hexaAMP has sufficient stability at room temperature and does not need special care during handling or shipment. Nevertheless, we recommend that the compound should be stored in the freezer, for longer storage periods preferably in freeze-dried form.

Soluble in water and aqueous buffers. Please rinse tube walls carefully and preferably use ultrasonic or vortex to achieve total and uniform mixing. When opening the tube please make sure that no substance is lost within the cap.

Cyclic oligoadenylates such as c-hexaAMP were found to be novel bacterial second messengers involved in the Type 3 CRISPR-CAS associated detection and degradation of invasive genetic elements in many prokaryotes. Upon recognition and binding of invasive target RNA, the Cas10 subunit of the type 3 interference complex generates cyclic oligoadenylates which in turn act as allosteric activators of Csm6 ribonucleases taht degrade invader-derived RNA transcripts. It is suggested that the size of cyclic oligoadenylate depends on the type 3 CRISPR-CAS system present, with c-hexaAMP being prodominant signaling molecule in Enterococcus italicus and Streptococcus thermophiles (all data according to Niewoehner et al., (2017) and Kazlauskiene et al., (2017) ) .