HEMTAC WEE1 degrader-1
HEMTAC WEE1 degrader-1 is a HSP90-mediated targeting chimera (HEMTAC) degrader of WEE1 (HSP90 enzyme inhibitory activity is IC50: 16.76 nM) . HEMTAC WEE1 degrader-1 promotes the ubiquitination and degradation of WEE1. HEMTAC WEE1 degrader-1 blocks the G2/M cell cycle. HEMTAC WEE1 degrader-1 has anticancer activity in acute myeloid leukemia (AML) patient-derived xenograft (PDX) models. HEMTAC WEE1 degrader-1 can be used in AML research. (Pink: HSP90 binder; Blue: WEE1 ligand; Black: linker) [1].
Product Specifications
CAS Number
3002417-64-0
UNSPSC
12352005
Target
HSP; Wee1
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Field of Research
Cancer
Purity
99.7800
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=NN=C(C2=CC(C(C)C)=C(O)C=C2O)N1C3=CC=C(CN4CCN(CC(NCCCCN5CCN(C6=CC=C(NC7=NC=C8C(N(C9=NC(C(C)(O)C)=CC=C9)N(CC=C)C8=O)=N7)C=C6)CC5)=O)CC4)C=C3)NCC
Molecular Formula
C57H71N15O6
Molecular Weight
1062.27
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HSP90
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
TNF alpha (J2D10), CF568 conjugate, 0.1mg/mL
IgA Secretory Component (SC05), CF594 conjugate, 0.1mg/mL
CD45 / LCA (2B11 + PD7/26), CF647 conjugate, 0.1mg/mL
