SC-57461A

SC-57461A is a potent, orally active, nonpeptide, and selective inhibitor of Leukotriene A4 (LTA4) hydrolase with IC50s of 2.5 nM, 3 nM, and 23 nM for recombinant human, mouse, and rat LTA4 hydrolase, respectively[1].

Product Specifications

CAS Number

[423169-68-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Aminopeptidase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/sc-57461a.html

Concentration

10mM

Purity

99.93

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(O)CCN(C)CCCOC1=CC=C(CC2=CC=CC=C2)C=C1.[H]Cl

Molecular Formula

C20H26ClNO3

Molecular Weight

363.88

Precautions

H302, H315, H319

References & Citations

[1]Leslie J Askonas, et al. Pharmacological characterization of SC-57461A (3-[methyl[3-[4- (phenylmethyl) phenoxy]propyl]amino]propanoic acid HCl), a potent and selective inhibitor of leukotriene A (4) hydrolase I: in vitro studies. J Pharmacol Exp Ther. 2002 Feb;300 (2) :577-82.|[2]T D Penning. Inhibitors of leukotriene A4 (LTA4) hydrolase as potential anti-inflammatory agents. Curr Pharm Des. 2001 Feb;7 (3) :163-79.|[3]James F Kachur, et al. Pharmacological characterization of SC-57461A (3-[methyl[3-[4- (phenylmethyl) phenoxy]propyl]amino]propanoic acid HCl), a potent and selective inhibitor of leukotriene A (4) hydrolase II: in vivo studies. J Pharmacol Exp Ther. 2002 Feb;300 (2) :583-7.