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MAC-545496

Product Specifications

CAS Number

838810-96-1

SKU

C17855-25mg

Target

Anti-infection

Applications

Microbiology

Smiles

C1CCN (CC1) C2=C (C=C (C=C2) C (=O) NC (=S) NC3=NC=C (C=C3) Cl) [N+] (=O) [O-]

Molecular Formula

C18H18ClN5O3S

Additionnal Information

MAC-545496 is a nanomolar glycopeptide-resistance-associated protein R (GraR) inhibitor with strong binding affinity to the full-length GraR protein (Kd ≤ 0.1 nM) . MAC-545496 can reverse β-lactam resistance in methicillin-resistant strains and synergize with CAMPs. MAC-545496 shows remarkable activity in macrophages and attenuates S. aureus virulence in a G. mellonella larvae infection model.

Storage Conditions

3 years -20°C powder

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