LDN-193189 2HCl

Product Specifications

CAS Number

1435934-00-1

Synonyms

DM-3189 2HCl

SKU

C12737-5mg

Target

TGF-beta/Smad

Applications

TGF-beta/Smad

Smiles

C1CN (CCN1) C2=CC=C (C=C2) C3=CN4C (=C (C=N4) C5=CC=NC6=CC=CC=C56) N=C3.Cl.Cl

Molecular Formula

C25H24Cl2N6

Additionnal Information

LDN-193189 (DM3189) 2HCl is a selective BMP signaling inhibitor, inhibits the ALK1, ALK2, ALK3 and ALK6 with IC50s of 0.8 nM, 0.8 nM, 5.3 nM and 16.7 nM in the kinase assay, respectively. LDN-193189 inhibits the transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50s of 5 nM and 30 nM in C2C12 cells, respectively, exhibits 200-fold selectivity for BMP versus TGF-β.