A-484954

A-484954 is a highly selective eukaryotic elongationfactor-2 kinase (eEF2K) inhibitor, with an IC50 of 280 nM.

Product Specifications

CAS Number

[142557-61-7]

UNSPSC

12352005

Hazard Statement

H301, H315, H319, H335

Target

Autophagy; CaMK

Type

Reference compound

Related Pathways

Autophagy; Neuronal Signaling

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/A-484954.html

Purity

99.57

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C(N1CC)N(C2CC2)C3=C(C=C(C(N)=O)C(N)=N3)C1=O

Molecular Formula

C13H15N5O3

Molecular Weight

289.29

Precautions

H301, H315, H319, H335

References & Citations

[1]Chen Z, et al. 1-Benzyl-3-cetyl-2-methylimidazolium iodide (NH125) induces phosphorylation of eukaryotic elongation factor-2 (eEF2) : a cautionary note on the anticancer mechanism of an eEF2 kinase inhibitor. J Biol Chem. 2011 Dec 23;286 (51) :43951-8.|[2]Kodama T, et al. Mechanisms underlying the relaxation by A484954, a eukaryotic elongation factor 2 kinase inhibitor, in rat isolated mesenteric artery. J Pharmacol Sci. 2018 May;137 (1) :86-92.|[3]Kameshima S, et al. Eukaryotic elongation factor 2 kinase mediates monocrotaline-induced pulmonary arterial hypertension via reactive oxygen species-dependent vascular remodeling. Am J Physiol Heart Circ Physiol. 2015 May 15;308 (10) :H1298-305.