Gly-Gly-Phe-Gly-NH-O-CO-Exatecan (hydrochloride)
Product Specifications
UNSPSC Description
Gly-Gly-Phe-Gly-NH-O-CO-Exatecan, as a drug-linker conjugate composed of linker Gly-Gly-Phe-Gly-NH-O-CO and Exatecan, can be used to prepare antibody conjugate drugs. Exatecan is a DNA topoisomerase I inhibitor that can be used in cancer research[1][2].
Target Antigen
Drug-Linker Conjugates for ADC; Topoisomerase
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related;Cell Cycle/DNA Damage
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gly-gly-phe-gly-nh-o-co-exatecan-hydrochloride.html
Smiles
CC1=C(F)C=C2C3=C1CC[C@H](NC(COCNC(CNC([C@H](CC4=CC=CC=C4)NC(CNC(CN)=O)=O)=O)=O)=O)C3=C5C(C(N6C5)=CC([C@@](O)(CC)C(OC7)=O)=C7C6=O)=N2.[H]Cl
Molecular Weight
877.31
References & Citations
[1]Joto N, et al. DX-8951f, a water-soluble camptothecin analog, exhibits potent antitumor activity against a human lung cancer cell line and its SN-38-resistant variant. Int J Cancer. 1997;72(4):680-686.|[2]Thomas A, et al. Antibody-drug conjugates for cancer therapy. Lancet Oncol. 2016;17(6):e254-e262.
Shipping Conditions
Blue Ice
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-13631F/Gly-Gly-Phe-Gly-NH-O-CO-Exatecan-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-13631F/Gly-Gly-Phe-Gly-NH-O-CO-Exatecan-hydrochloride-SDS-MedChemExpress.pdf
CAS Number
3053688-78-8
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
