7BIO

Product Specifications

CAS Number

916440-85-2

Synonyms

7-bromoindirubin-3-oxime

SKU

C01262-5mg

Target

CDK

Applications

Cell Cycle

Smiles

O\N=C1\C (NC2=CC=CC=C12) =C/3C (=O) NC4=C (Br) C=CC=C34

Additionnal Information

7-bromoindirubin-3-oxime (7BIO), an indirubin derivative derived from indirubin-3-oxime, possesses inhibitory effects against cyclin-dependent kinase-5 (CDK5) and glycogen synthase kinase-3β (GSK3β), also potently inhibits Aβ oligomer-induced neuroinflammation, synaptic impairments, tau hyper-phosphorylation, and activation of astrocytes and microglia.