Coniferaldehyde

Coniferaldehyde (4-Hydroxy-3-methoxycinnamaldehyde) is an effective inducer of heme oxygenase-1 (HO-1) . Coniferaldehyde inhibits LPS-induced apoptosis through the PKCα/β II/Nrf-2/HO-1 dependent pathway in RAW264.7 macrophage cells. Coniferaldehyde has antioxidant and anti-inflammatory activities[1].

Product Specifications

CAS Number

[458-36-6]

Product Name Alternative

4-Hydroxy-3-methoxycinnamaldehyde

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Apoptosis; Keap1-Nrf2

Type

Natural Products

Related Pathways

Apoptosis; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/coniferaldehyde.html

Concentration

10mM

Purity

99.94

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C/C=C/C1=CC=C(O)C(OC)=C1

Molecular Formula

C10H10O3

Molecular Weight

178.19

Precautions

H315, H319, H335

References & Citations

[1]Kim KM, et al. Coniferaldehyde inhibits LPS-induced apoptosis through the PKC α/β II/Nrf-2/HO-1 dependent pathway in RAW264.7 macrophage cells. Environ Toxicol Pharmacol. 2016 Dec;48:85-93.|[2]Dawei Cai, et al. Coniferaldehyde prevents articular cartilage destruction in a murine model via Nrf2/HO‑1 pathway. Mol Med Rep. 2021 Mar;23 (3) :224.