Fipronil

Fipronil is a broad-spectrum insecticide effective against Lepidoptera species as well as thrips, locusts, ants, cockroaches, fleas and ticks. Fipronil selectively inhibits GABA receptor with IC50s of 30 nM and 1600 nM for cockroach and rat GABA receptors, respectively. Glutamate-gated chloride channels (GluCls), which are present in cockroaches but not in mammals, are sensitive to the blocking effect of Fipronil. Fipronil also induces apoptosis in HepG2 cells and promotes the expression of CYP1A1 and CYP3A4 mRNA in human hepatocytes[1][2].

Product Specifications

CAS Number

[120068-37-3]

UNSPSC

12352005

Hazard Statement

H301+H311+H331, H372

Target

Apoptosis; Cytochrome P450; GABA Receptor

Type

Reference compound

Related Pathways

Apoptosis; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/fipronil.html

Purity

99.49

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

N#CC1=NN(C2=C(Cl)C=C(C(F)(F)F)C=C2Cl)C(N)=C1S(C(F)(F)F)=O

Molecular Formula

C12H4Cl2F6N4OS

Molecular Weight

437.15

Precautions

H301+H311+H331, H372

References & Citations

[1]Das PC, et al. Fipronil induces CYP isoforms and cytotoxicity in human hepatocytes. Chem Biol Interact. 2006 Dec 15;164 (3) :200-14. |[2]Narahashi T, et al. Glutamate-activated chloride channels: Unique fipronil targets present in insects but not in mammals. Pestic Biochem Physiol. 2010 Jun 1;97 (2) :149-152.