HCAXII-IN-9
HCAXII-IN-9 (Compound 3I) is a selective inhibitor of hCAXII with Ki values of 28 nM, 7192.6 nM, 188.6 nM, and >100000 nM for hCAXII, hCAI, hCAII, and hCAIX, respectively. hCAXII-IN-9 can be utilized in antitumor research[1].
Product Specifications
UNSPSC
12352005
Target
Carbonic Anhydrase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hcaxii-in-9.html
Solubility
10 mM in DMSO
Smiles
COC1=CC=C(OC)C(C(P(OCC)(OCC)=O)NC2=CC=C(S(NC3=NC=CC=C3)(=O)=O)C=C2)=C1
Molecular Formula
C24H30N3O7PS
Molecular Weight
535.55
References & Citations
[1]Bekheit MS, et al. Novel sulfonamide-phosphonate conjugates as carbonic anhydrase isozymes inhibitors. Drug Dev Res. 2024 Feb;85 (1) :e22135. doi: 10.1002/ddr.22135. Epub 2023 Nov 23. PMID: 37997034.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CA II; CA I; CA IX; CA XII
Frequently Asked Questions
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