Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

DMOG

DMOG (Dimethyloxallyl Glycine) is a cell permeable and competitive inhibitor of HIF-PH, which results in HIF-1α stabilisation and accmulation in vitro and in vivo[1]. DMOG is an α-ketoglutarate analogue and inhibits α-KG-dependent hydroxylases. DMOG acts as a pro-angiogenic agent and plays a protective role in experimental model of colitis and diarrhoea via HIF-1 related signal[2][4]. DMOG induces cell autophagy[5].

Product Specifications

CAS Number

89464-63-1

Product Name Alternative

Dimethyloxallyl Glycine

UNSPSC

12352211

Hazard Statement

H302

Target

Autophagy; HIF/HIF Prolyl-Hydroxylase

Type

Reference compound

Related Pathways

Autophagy; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/DMOG.html

Purity

99.77

Solubility

DMSO : 125 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)

Smiles

O=C(OC)CNC(C(OC)=O)=O

Molecular Formula

C6H9NO5

Molecular Weight

175.14

Precautions

H302

References & Citations

[1]Baader E, et al. Inhibition of prolyl 4-hydroxylase by oxalyl amino acid derivatives in vitro, in isolated microsomes and in embryonic chicken tissues. Biochem J. 1994 Jun 1;300 (Pt 2) :525-30.|[2]Milkiewicz M, et al. Inhibition of endogenous HIF inactivation induces angiogenesis in ischaemic skeletal muscles of mice. J Physiol. 2004 Oct 1;560 (Pt 1) :21-6.|[3]Schultz K, et al. Prolyl hydroxylase 2 deficiency limits proliferation of vascular smooth muscle cells by hypoxia-inducible factor-1{alpha}-dependent mechanisms. Am J Physiol Lung Cell Mol Physiol. 2009 Jun;296 (6) :L921-7.|[4]Li X, et al. Up-regulation of hypoxia-inducible factor-1α enhanced the cardioprotective effects of ischemic postconditioning in hyperlipidemic rats. Acta Biochim Biophys Sin (Shanghai) . 2014 Feb;46 (2) :112-8.|[5]Singh A, et al. Hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors induce autophagy and have a protective effect in an in-vitro ischaemia model.Sci Rep. 2020 Jan 31;10 (1) :1597.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Human AMIGO2 Protein, His Tag
AM2-H52H5-100ug 100 µg

Human AMIGO2 Protein, His Tag

Sign In for Pricing
View Details
Elab Fluor® 647 Anti-Mouse IL-17A Antibody[TC11-18H10.1]
E-AB-F1199M-01 50 Tests

Elab Fluor® 647 Anti-Mouse IL-17A Antibody[TC11-18H10.1]

Sign In for Pricing
View Details
Elab Fluor® 647 Anti-Mouse IL-17A Antibody[TC11-18H10.1]
E-AB-F1199M-02 100 Tests

Elab Fluor® 647 Anti-Mouse IL-17A Antibody[TC11-18H10.1]

Sign In for Pricing
View Details
Elab Fluor® 647 Anti-Mouse IL-17A Antibody[TC11-18H10.1]
E-AB-F1199M-03 2x 100 Tests

Elab Fluor® 647 Anti-Mouse IL-17A Antibody[TC11-18H10.1]

Sign In for Pricing
View Details
Human SPDYE5 activation kit by CRISPRa
GA118549 1 Kit

Human SPDYE5 activation kit by CRISPRa

Sign In for Pricing
View Details
8-Dehydrocholesterol
TRC-D230295-25MG 25 mg

8-Dehydrocholesterol

Sign In for Pricing
View Details