Elab Fluor® 647 Anti-Mouse IL-17A Antibody[TC11-18H10.1]
Product Specifications
Background
IL-17, also known as CTLA-8, is a T cell-expressed pleiotropic cytokine that exhibits a high degree of homology to a protein encoded by the ORF13 gene of herpes virus Saimiri. IL-17 is produced by Th cells (Th17) that are distinct from the traditional Th1- and Th2-cell subsets. IL-23 plays an important role in triggering IL-17 production. Both recombinant and natural IL-17 have been shown to exist as disulfide linked homodimers. IL-17 exhibits multiple biological activities on a variety of cells including: the induction of IL-6 and IL-8 production in fibroblasts, activation of NF-κB, and costimulation of T cell proliferation. IL-17 is an essential inflammatory mediator in the development of autoimmune diseases. Neutralization of IL-17 with monoclonal antibody is able to ameliorate the disease course.
Abbreviation
IL-17A
Gene ID
16171
UniProt
Q62386
Host
Rat
Reactivity
Mouse
Target
CTLA-8; CTLA8; Cytotoxic T-lymphocyte-associated antigen 8; IL-17; IL-17A; Interleukin-17A
Clonality
Monoclonal
Clone
TC11-18H10.1
Conjugation
Elab Fluor®647
Applications
ICFCM
Field of Research
Cell Biology; Immunology; Neuroinflammation; Neuroscience
Concentration
5 μL/Test
Buffer
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.
Product Datasheet
https://789.bio/ea/mvxtal
Product MSDS
https://789.bio/eb/X1iff1
Recommended Usage
The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood) .
Isotype
Rat IgG1, κ
Available Sizes
Curated Selection
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