NAPQI
NAPQI is the toxic metabolite of Acetaminophen (HY-66005) . NAPQI is also an inhibitor of enzymes in the vitamin K cycle. NAPQI is rapidly detoxified by glutathione (GSH), but in situations of GSH deficiency, excess NAPQI reacts with cysteine residues in proteins, causing cell death and toxicity in the liver[1][2].
Product Specifications
CAS Number
[50700-49-7]
Product Name Alternative
N-Acetyl-4-benzoquinone Imine
UNSPSC
12352211
Hazard Statement
H315, H319
Target
Drug Metabolite; Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/napqi.html
Purity
99.67
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(/N=C1C=CC(C=C\1)=O)=O
Molecular Formula
C8H7NO2
Molecular Weight
149.15
Precautions
H315, H319
References & Citations
Shipping Conditions
Dry Ice
Storage Conditions
-80°C, protect from light, stored under nitrogen
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite
Available Sizes
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