SIRT1-IN-1

SIRT1-IN-1 is a selective SIRT1 inhibitor with an IC50 of 0.205 μM. SIRT1-IN-1 inhibits SIRT2 with an IC50 of 11.5 μM[1]. SIRT1-IN-1, a indole, is a cytomegalovirus (CMV) inhibitors and has antiviral activity[2].

Product Specifications

CAS Number

[352554-02-0]

UNSPSC

12352005

Target

CMV; Sirtuin

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage; Epigenetics

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/sirt1-in-1.html

Purity

98.15

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1C(NC2=C3C=C(C)C=C2)=C3CCC1)N

Molecular Formula

C14H16N2O

Molecular Weight

228.29

References & Citations

[1]Andrew D Napper, et al. Discovery of Indoles as Potent and Selective Inhibitors of the Deacetylase SIRT1. J Med Chem. 2005 Dec 15;48 (25) :8045-54.|[2]Thomas Shenk, et al. Sirtuin Modulators as Inhibitors of Cytomegalovirus. US20160296523A1.