Fluorescent DOTAP

Fluorescent DOTAP (NBD-DOTAP) is a cationic lipid which can be used for nucleic acid and protein delivery. Fluorescent DOTAP is labeled with a fluorophore NBD (maximum excitation/emission wavelength ∼463/536 nm) . Fluorescent DOTAP can be used for gene delivery systems, drug delivery, as well as cell imaging and nanocarrier tracking. Fluorescent DOTAP is an ideal candidate for both biological and pharmaceutical formulation (e.g. co-delivery of vaccines) research[1][3].

Product Specifications

CAS Number

[1010076-97-7]

Product Name Alternative

NBD-DOTAP

UNSPSC

12352200

Target

Fluorescent Dye; Liposome

Type

Biochemical Assay Reagents

Related Pathways

Metabolic Enzyme/Protease; Others

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/fluorescent-dotap.html

Purity

98.00

Solubility

DMSO : 20 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CCCCCCCC/C=C\CCCCCCCC(OCC(OC(CCCCCNC1=CC=C([N+]([O-])=O)C2=NON=C21)=O)C[N+](C)(C)C)=O.[Cl-]

Molecular Formula

C36H60ClN5O7

Molecular Weight

710.34

References & Citations

[1]Simberg, D., et al., (2004) . DOTAP (and other cationic lipids) : chemistry, biophysics, and transfection. Critical reviews in therapeutic drug carrier systems, 21 (4), 257-317.|[2]Matos, A. L. L., et al., (2017) . Delivery of cationic quantum dots using fusogenic liposomes in living cells. Journal of photochemistry and photobiology. B, Biology, 171, 43-49.|[3]Chen, W., et al., (2008) . A simple but effective cancer vaccine consisting of an antigen and a cationic lipid. Cancer immunology, immunotherapy : CII, 57 (4), 517-530.