(2R,3S) -Emricasan
(2R,3S) -Emricasan ((2R,3S) -PF 03491390) is an isomer of Emricasan. Emricasan is an orally active and irreversible pan-caspase inhibitor. Emricasan inhibits Zika virus (ZIKV) -induced increases in caspase-3 activity and protected human cortical neural progenitors[1].
Product Specifications
CAS Number
409369-54-6
Product Name Alternative
(2R,3S) -PF 03491390; (2R,3S) -IDN-6556
UNSPSC
12352101
Target
Caspase; Flavivirus
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/2r-3s-emricasan.html
Smiles
FC1=C(C(F)=C(C=C1F)F)OCC([C@@H](NC([C@H](NC(C(NC2=C(C=CC=C2)C(C)(C)C)=O)=O)C)=O)CC(O)=O)=O
Molecular Formula
C26H27F4N3O7
Molecular Weight
569.50
References & Citations
[1]Gracia-Sancho J, et al. Emricasan Ameliorates Portal Hypertension and Liver Fibrosis in Cirrhotic Rats Through a Hepatocyte-Mediated Paracrine Mechanism. Hepatol Commun. 2019 Apr 22;3 (7) :987-1000.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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