2-Methylthiophenothiazine

2-Methylthiophenothiazine (compound 17) is a precursor of tubulin inhibitor with potential anticancer activity and can inhibit tubulin aggregation[1][2].

Product Specifications

CAS Number

[7643-08-5]

UNSPSC

12352005

Hazard Statement

H302, H317, H373, H410

Target

Microtubule/Tubulin

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Field of Research

Cancer

Purity

99.77

Smiles

CSC1=CC(NC2=CC=CC=C2S3)=C3C=C1

Molecular Formula

C13H11NS2

Molecular Weight

245.36

Precautions

H302, H317, H373, H410

References & Citations

[1]Prinz H, et al. N-benzoylated phenoxazines and phenothiazines: synthesis, antiproliferative activity, and inhibition of tubulin polymerization. J Med Chem. 2011 Jun 23;54 (12) :4247-63.|[2]Glass-Marmor L, et al. Calmodulin antagonists decrease glucose 1,6-bisphosphate, fructose 1,6-bisphosphate, ATP and viability of melanoma cells. Eur J Pharmacol. 1996 Oct 17;313 (3) :265-71.