Mongersen

Mongersen (GED-0301) is a specific and orally active SMAD7 antisense oligonucleotide. Mongersen restores TGF-β1 activity leading to inhibition of inflammatory signals. Mongersen can attenuate Crohn's disease-like experimental colitis in mice[1][2].

Product Specifications

CAS Number

[1443994-46-4]

Product Name Alternative

GED-0301

UNSPSC

12352208

Target

TGF-beta/Smad

Type

Oligonucleotides

Related Pathways

Stem Cell/Wnt; TGF-beta/Smad

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/mongersen.html

Purity

95.25

Solubility

H2O : 20 mg/mL (ultrasonic)

Smiles

[Mongersen]

Molecular Formula

C200H241N69O107P20S20

Molecular Weight

6604

References & Citations

[1]Monteleone G, et, al. Mongersen, an oral SMAD7 antisense oligonucleotide, and Crohn's disease. N Engl J Med. 2015 Mar 19;372 (12) :1104-13.|[2]Izzo R, et, al. Knockdown of Smad7 With a Specific Antisense Oligonucleotide Attenuates Colitis and Colitis-Driven Colonic Fibrosis in Mice. Inflamm Bowel Dis. 2018 May 18;24 (6) :1213-1224.