Azido-PEG2-C2-amine

Azido-PEG2-C2-amine (N3-PEG2-CH2CH2NH2) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG2-C2-amine is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [2]. Azido-PEG2-C2-amine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Product Specifications

CAS Number

[166388-57-4]

Product Name Alternative

N3-PEG2-CH2CH2NH2

UNSPSC

12352203

Hazard Statement

H314

Target

ADC Linker; PROTAC Linkers

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/azido-peg2-c2-amine.html

Purity

99.85

Solubility

DMSO : ≥ 100 mg/mL

Smiles

[N-]=[N+]=NCCOCCOCCN

Molecular Formula

C6H14N4O2

Molecular Weight

174.20

Precautions

H314

References & Citations

[1]Su S, et al. Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 22;62 (16) :7575-7582.|[2]Tominari, Yusuk , et al. Heterocyclic compound. WO2020027225A1.