Recombinant Human IGFBP7 Protein, hFc Tag

Molecular Characterization: hFc (Glu99-Ala330) IGFBP7 (Asp30-Leu282) Molecular weight: The protein has a predicted molecular mass of 52.3 kDa after removal of the signal peptide. The apparent molecular mass of hFc-IGFBP7 is approximately 55-70 kDa due to glycosylation.Description: Recombinant human IGFBP7 Protein with N-terminal Human Fc tagThis gene encodes a member of the insulin-like growth factor (IGF) -binding protein (IGFBP) family. IGFBPs bind IGFs with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its receptors. This protein binds IGF-I and IGF-II with relatively low affinity, and belongs to a subfamily of low-affinity IGFBPs. It also stimulates prostacyclin production and cell adhesion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and one variant has been associated with retinal arterial macroaneurysm (PMID: 21835307) .