Recombinant Human NTRK3 Protein, hFc Tag

Molecular Characterization: NTRK3 (Cys32-Thr429) hFc (Glu99-Ala330) Molecular weight: The protein has a predicted molecular mass of 70.9 kDa after removal of the signal peptide.The apparent molecular mass of NTRK3-hFc is approximately 100-130 kDa due to glycosylation.Description: Recombinant human NTRK3 protein with C-terminal human Fc tagThis gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene.

Product Specifications

Product Name Alternative

Gp145 (trkC), GP145-TrkC, TRKC

UniProt

Q16288

Host

HEK293

Target Antigen

NTRK3

Components

Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization.

Storage Conditions

Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing) . Lyophilized proteins are shipped at ambient temperature.