AAK1-IN-6

AAK1-IN-6 (Compound 23) is an inhibitor of AP-2-associated protein kinase 1 (AAK1, IC50 = 12 nM) with antiviral activity against the dengue virus (DNEV2, EC50 = 0.24 μM) and Venezuelan equine encephalitis virus (VEEV, EC50 = 0.30 μM) . AAK1-IN-6 can be utilized in antiviral research[1].

Product Specifications

CAS Number

[3061058-16-7]

UNSPSC

12352005

Target

AAK1; Dengue Virus

Type

Reference compound

Related Pathways

Anti-infection; Neuronal Signaling

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/aak1-in-6.html

Smiles

COC1=C(OC)C=C(C2=CN=C(NC=C3C4=CN=C(C5=CC=CC=C5)O4)C3=C2)C=C1

Molecular Formula

C24H19N3O3

Molecular Weight

397.43

References & Citations

[1]Ravi NP, et al. Synthesis of 3-heteroaryl-pyrrolo[2,3-b]pyridines as potent inhibitors of AP-2-associated protein kinase 1 (AAK1) with antiviral activity. Eur J Med Chem. 2024 Dec 15;280:116967.