Gosogliptin

Gosogliptin is a potent and selective inhibitor of dipeptidyl peptidase-IV (DPP-IV) .

Product Specifications

CAS Number

[869490-23-3]

Product Name Alternative

PF-00734200; PF-734200

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Dipeptidyl Peptidase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/Gosogliptin.html

Purity

99.83

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C([C@H](C1)NC[C@H]1N2CCN(CC2)C3=NC=CC=N3)N4CC(CC4)(F)F

Molecular Formula

C17H24F2N6O

Molecular Weight

366.41

Precautions

H302, H315, H319, H335

References & Citations

[1]Dai H, et al. The pharmacokinetics of PF-734200, a DPP-IV inhibitor, in subjects with renal insufficiency. Br J Clin Pharmacol. 2011 Jul;72 (1) :85-91.|[2]Sharma R, et al. Metabolism, excretion, and pharmacokinetics of ((3,3-difluoropyrrolidin-1-yl) ((2S,4S) -4- (4- (pyrimidin-2-yl) piperazin-1-yl) pyrrolidin-2-yl) methanone, a dipeptidyl peptidase inhibitor, in rat, dog and human. Drug Metab Dispos. 2012 Nov;40 (11) :2143-61.