Pacific Blue Conjugated Anti-CD105 / Endoglin Monoclonal Antibody (Clone:MEM-226)
CD105 (Endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFbetaR-2 as a receptor for TGFbeta-1 and TGFbeta-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFbeta-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels.
Product Specifications
Product Name Alternative
ENG||END||Endoglin||HHT1||ORW1
Gene Name
ENG
Gene ID
2022
UniProt
P17813
Host
Mouse
Reactivity
Rat, Human
Immunogen
Recombinant Vaccinia virus containing the human CD105 cDNA.
Target Antigen
CD105
Clonality
Monoclonal
Clone
MEM-226
Applications
FACS
Purification
Components
Formulation: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Storage Conditions
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Applications Notes
Isotype
Mouse IgG2a
Frequently Asked Questions
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