Anti-IgE Monoclonal Antibody (Clone:4H10)
Immunoglobulin E (IgE) is a 180 kDa soluble protein serving as an antigen-specific unit of mast cell effector mechanisms. IgE has the lowest serum concentration of all immunoglobulins (approximately 0.5 mg/l) in healthy individuals, but upon allergen challenge its concentration in blood increases dramatically. Although biological survival of free IgE is very short (T1/2 = 2 days), it is stabilized after binding to its high affinity receptor. Unlike IgM- IgG- and IgA-committed B cells, IgE-switched B cells do not undergo clonal expansion.
Product Specifications
Product Name Alternative
Immunoglobulin heavy constant epsilon
Gene Name
IGHE
UniProt
P01854
Host
Mouse
Reactivity
Human
Immunogen
Purified human IgE.
Target Antigen
IgE
Clonality
Monoclonal
Clone
4H10
Applications
ELISA, FACS, WB
Purification
Purified by precipitation and chromatography
Format
Purified
Components
1mg/mL, Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Storage Conditions
Store at 2-8°C. Do not freeze.
Applications Notes
Flow Cytometry Recommended dilution:4 μg/mL
Isotype
Mouse IgG1
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