SOS1-IN-17
Product Specifications
UNSPSC Description
SOS1-IN-17 (Compound 8d) is an orally active inhibitor for SOS1-KRASG12C interaction with an IC50 of 5.1 nM. SOS1-IN-17 inhibits ERK phosphorylation in DLD-1 cell with an IC50 of 18 nM. SOS1-IN-17 exhibits anti-proliferative activity in KRASG12C mutated Mia-Paca-2 cell with an IC50 of 0.11 μM. SOS1-IN-17 exhibits antitumor efficacy against pancreatic cancer in mouse model[1].
Target Antigen
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein;MAPK/ERK Pathway
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sos1-in-17.html
Smiles
FC1=C(C(F)F)C=CC=C1[C@H](NC2=NC(C)=NC3=C2C=C4C(OCCN4C(C5CCN(C(C)C)CC5)=O)=C3)C
Molecular Weight
541.61
References & Citations
[1]Qing L, et al., Novel potent SOS1 inhibitors containing a tricyclic quinazoline scaffold: A joint view of experiments and simulations. Eur J Med Chem. 2025 Jan 15;282:117065.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-168716/SOS1-IN-17-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-168716/
Clinical Information
No Development Reported
Curated Selection
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