SOS1-IN-17

SOS1-IN-17 (Compound 8d) is an orally active inhibitor for SOS1-KRASG12C interaction with an IC50 of 5.1 nM. SOS1-IN-17 inhibits ERK phosphorylation in DLD-1 cell with an IC50 of 18 nM. SOS1-IN-17 exhibits anti-proliferative activity in KRASG12C mutated Mia-Paca-2 cell with an IC50 of 0.11 μM. SOS1-IN-17 exhibits antitumor efficacy against pancreatic cancer in mouse model[1].

Product Specifications

UNSPSC

12352211

Target

Ras; SOS1

Type

Reference compound

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sos1-in-17.html

Smiles

FC1=C(C(F)F)C=CC=C1[C@H](NC2=NC(C)=NC3=C2C=C4C(OCCN4C(C5CCN(C(C)C)CC5)=O)=C3)C

Molecular Formula

C29H34F3N5O2

Molecular Weight

541.61

References & Citations

[1]Qing L, et al., Novel potent SOS1 inhibitors containing a tricyclic quinazoline scaffold: A joint view of experiments and simulations. Eur J Med Chem. 2025 Jan 15;282:117065.