Recombinant Rabbit Monoclonal Antibody to NKX2.2 (Neuroendocrine & Ewing s Sarcoma Marker) (Clone : NX2/1422R)
Selected Variant
12-1032-100
Size: 100 µg
Expression of NKX2.2 has been found in neuroendocrine tumors of the gut, making it a potential marker for the study of gastrointestinal neuroendocrine tumors. More recently, NKX2.2 protein was identified as a target of EWS-FLI-1, the fusion protein specific to Ewing sarcoma, and was shown to be differentially upregulated in Ewing sarcoma on the basis of array-based gene expression analysis. It acts as a valuable marker for Ewing sarcoma, with a sensitivity of 93% and a specificity of 89%, and aids in the differential diagnosis of small round cell tumors.
Product Specifications
Product Name Alternative
Homeobox protein NK-2 homolog B, NK2 transcription factor like protein B, NK2 transcription factor related locus 2, NKX22, Nkx2b, tinman
Gene Name
NKX2-2
Gene ID
4821
UniProt
O95096
Reactivity
Human
Immunogen
Recombinant human NKX2.2 protein fragment (exact sequence is proprietary)
Target Antigen
NKX2.2 (Neuroendocrine & Ewing s Sarcoma Marker)
Clonality
Monoclonal
Clone
NX2/1422R
Applications
IHC
Purification
Purified Ab with BSA and Azide at 200ug/ml
Format
Purified
Components
200ug/mL of Ab purified by Protein A. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/mL.
Storage Conditions
Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Isotype
Rabbit IgG
Price
Frequently Asked Questions
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