Polyclonal Antibody to CADM1

Cell Adhesion Molecule 1 (CADM1) encodes a multifunctional immunoglobulin-like cell adhesion molecule whose cytoplasmic domain contains a type II PSD95/Dlg/ZO-1 (PDZ) -binding motif (BM) for associating with other intracellular proteins. CADM1 lacks expression in T lymphocytes of healthy individuals and is overexpressed in adult T-cell leukemia-lymphoma (ATL) cells. CADM1 generates a membrane-associated C-terminal fragment, AlphaCTF, through A disintegrin- and metalloprotease-10-mediated ectodomain shedding, subsequently releasing the intracellular domain (ICD) through gamma-secretase-mediated intramembrane shedding of alphaCTF. alphaCTF localizes to mitochondria and induces apoptosis in lung epithelial cells. In women with multiple cervical biopsies, CADM1/MAL methylation increases with severity of the lesion and is lesion-specific. CADM1/MAL methylation status in cervical scrapes appears to be representative of the worst underlying lesion, particularly for CIN3 and cervical cancer.