Monoclonal Antibody to FOXO1 (Clone: ABM4E66)
FOXO1 is one of the fox proteins playing pivotal roles in several human intracellular pathways. These proteins are transcription factors acting as nuclear regulator of transcriptional activity of a number of metabolic processes such as the cellular response to oxidative stress. FOXO1 protein response to oxidative stress may be linked to Alzheimer's disease (AD) by means of insulin brain resistance. FOXO1 plays a critical role in establishing and maintaining the B cell specific differentiation program, but it is also responsible for cell death due to an inappropriate BCR signaling. This protein is highly expressed in B cells, is downregulated in Hodgkin and Reed-Sternberg (HRS) cells of cHL (Classical Hodgkin Lymphoma) .
Product Specifications
Product Name Alternative
FOXO1||FKHR||FOXO1A
Gene Name
FOXO1
Gene ID
2308
UniProt
Q12778
Host
Mouse
Reactivity
Human
Immunogen
A full length recombinant FOXO1 protein was used as the immunogen for this antibody.
Target Antigen
FOXO1
Clonality
Monoclonal
Clone
ABM4E66
Applications
FACS, WB
Purification
Protein G Chromatography
Format
Purified
Components
25 μg in 50 μl/100 μg in 200 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage Conditions
Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Western blot analysis: 2-4 μg/mL, FACS: 0.5-1 μg/10^6 cells
Isotype
Mouse IgG2b Kappa
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