Monoclonal antibody to CD161 (clone: ABM27F5)
CD161 is the human equivalent of mouse NK cell receptor P1A. It is a type II transmembrane glycoprotein with characteristics of the C-type lectin superfamily. The expression confines to lymphocytes found in human gut and liver, as well as blood, especially NK (natural killer) cells, Th17 (T helper 17) cells, and a population of unconventional T cells known as MAIT (mucosal-associated invariant T) cells. CD161 promotes T cell expansion and eventually has been identified as a marker of human IL-17-producing T cells. It plays a pivotal role in trans-endothelial migration and is also implicated in the pathogenesis of RA (rheumatoid arthritis) as well as graft-versus-host disease (GVHD) .
Product Specifications
Product Name Alternative
Gene Name
KLRB1
Gene ID
3820
UniProt
Q12918
Host
Mouse
Reactivity
Human
Immunogen
Full length recombinant protein of hCD161 was used as the immunogen for this antibody.
Target Antigen
CD161
Clonality
Monoclonal
Clone
ABM27F5
Applications
FACS
Purification
Protein G Chromatography
Format
Purified
Components
25 μg in 50 μl/100 μg in 200 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage Conditions
Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
FACS analysis: 0.5-1 μg/10^6 cells
Isotype
Mouse IgG2b, Kappa
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