NB-598 (Maleate)
Product Specifications
UNSPSC Description
NB-598 Maleate is a potent and competitive inhibitor of squalene epoxidase (SE), and suppresses triglyceride biosynthesis through the farnesol pathway. NB-598 (Maleate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Target Antigen
Others
Type
Reference compound
Related Pathways
Others
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/NB-598-Maleate.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(O)/C=C\C(O)=O.CC(C)(C)C#C/C=C/CN(CC)CC1=CC(OCC2=CC(C3=CSC=C3)=CS2)=CC=C1
Molecular Weight
565.74
References & Citations
[1]Xia F, et al. Inhibition of cholesterol biosynthesis impairs secretion and voltage-gated calcium channel function in pancreatic beta-cells. Endocrinology. 2008 Oct;149(10):5136-45.|[2]Horie M, et al. Effects of NB-598, a potent squalene epoxidase inhibitor, on the apical membrane uptake of cholesterol and basolateral membrane secretion of lipids in Caco-2 cells. Biochem Pharmacol. 1993 Jul 20;46(2):297-305.|[3]Horie M, et al. An inhibitor of squalene epoxidase, NB-598, suppresses the secretion of cholesterol and triacylglycerol and simultaneously reduces apolipoprotein B in HepG2 cells. Biochim Biophys Acta. 1993 May 20;1168(1):45-51.Cell Death Dis. 2021 May 13;12(5):482.|Cell Rep. 2020 Aug 4;32(5):107944.|Nat Chem Biol. 2016 Jul;12(7):497-503. |University of Toronto. Department of Medical Biophysics|Adv Sci (Weinh). 2023 Sep;10(27):e2206878.|Antioxidants (Basel). 2024 Jun 13;13(6):722.|Cancer Res. 2022 Sep 2;82(17):3032-3044.|Cell Chem Biol. 2021 Feb 16;S2451-9456(21)00051-9.|Cell Metab. 2020 Apr 7;31(4):862-877.e14.|Genome Biol. 2016 Jun 29;17(1):140. |J Steroid Biochem Mol Biol. 2015 Aug;152:34-44.|Sci China Life Sci. 2021 May 27;1-21.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-16343C/NB-598-Maleate-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-16343C/NB-598-Maleate-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
155294-62-5
Available Sizes
Curated Selection
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