Dexketoprofen (trometamol)

Dexketoprofen trometamol (Dexketoprofen tromethamine salt) is an orally active non-selective COX inhibitor. Dexketoprofen trometamol has a pain-relieving effect, anti-inflammatory effect and anti-cancer effect[1][2][3][4][5].

Product Specifications

CAS Number

[156604-79-4]

Product Name Alternative

Dexketoprofen (tromethamine salt)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

COX

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/dexketoprofen-trometamol.html

Purity

99.73

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=CC=C1)C2=CC([C@H](C)C(O)=O)=CC=C2.NC(CO)(CO)CO

Molecular Formula

C20H25NO6

Molecular Weight

375.42

Precautions

H302, H315, H319, H335

References & Citations

[1]Magdi Hanna, et al. A review of dexketoprofen trometamol in acute pain. Curr Med Res Opin. 2019 Feb;35 (2) :189-202.|[2]Romero-Alejo E, et al. Antihyperalgesic effects of dexketoprofen and tramadol in a model of postoperative pain in mice - effects on glial cell activation. J Pharm Pharmacol. 2016 Aug;68 (8) :1041-50. |[3]Büyükfidan D, et al. The effects of dexketoprofen trometamol on incisional wound healing in a rat model: 9AP7-7[J]. European Journal of Anaesthesiology| EJA, 2011, 28: 144-145.|[4]Marinov L, et al. The effects of meloxicam, lornoxicam, ketoprofen, and dexketoprofen on human cervical, colorectal, and mammary carcinoma cell lines[J]. Pharmacia, 2024, 71: 1-12.|[5]Soliman S M, et al. The deleterious effect of xylene-induced ear edema in rats: protective role of dexketoprofen trometamol transdermal invasomes via inhibiting the oxidative stress/NF-κB/COX-2 pathway[J]. International Journal of Pharmaceutics, 2023, 631: 122525.