Anti-Phospho-ITPR1 (S1756) Antibody
Boster Bio Anti-Phospho-ITPR1 (S1756) Antibody catalog # P01465. Tested in WB, ICC, IF applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Background
Inositol 1,4,5-trisphosphate receptor type 1, also known as IP3R or IP3R1, is a protein that in humans is encoded by the ITPR1 gene. It is mapped to 3p26.1. The product of the ITPR1 gene is predominantly enriched in cerebellar Purkinje cells but is also concentrated in neurons in the hippocampal CA1 region, caudate-putamen, and cerebral cortex. The ITPR1 gene encodes the inositol 1,4,5-triphosphate (IP3) receptor, an intracellular IP3-gated calcium channel that modulates intracellular calcium signaling. Upon stimulation by inositol 1,4,5-trisphosphate, this receptor mediates calcium release from the endoplasmic reticulum. Mutations in ITPR1 cause spinocerebellar ataxia type 15, a disease associated with an heterogeneous group of cerebellar disorders.
Synonyms
INSP3R1; IP3 receptor isoform 1; IP3R; IP3R 1; IP3R1; ITPR1; SCA15; SCA16; Type 1 InsP3 receptor
Gene Name
ITPR1
UniProt
Q14643
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A synthesized peptide derived from RAT IP3 Receptor (P29994) around the phosphorylation site of Ser1756. This site is equivalent to Ser1764 in the human IP3 receptor sequence.
Clonality
Polyclonal
Applications
WB, ICC, IF
Purification
Protein A affinity purified.
Concentration
500 μg/mL
Form
Liquid
Storage Conditions
12 months from date of receipt, -20°C as supplied. 6 months 2 to 8°C after reconstitution. Avoid repeated freezing and thawing.
Contents
500 μg/mL antibody with PBS,0.02% NaN3, 1 mg BSA and 50% glycerol.
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