Anti-HNRNPU Antibody (C-term)
Boster Bio Anti-HNRNPU Antibody (C-term) (Catalog # M03691-1) . Tested in WB application (s) . This antibody reacts with Human, Mouse.
Product Specifications
Background
Component of the CRD-mediated complex that promotes MYC mRNA stabilization. Binds to pre-mRNA. Has high affinity for scaffold-attached region (SAR) DNA. Binds to double- and single- stranded DNA and RNA. Plays a role in the circadian regulation of the core clock component ARNTL/BMAL1 transcription (By similarity) .
Synonyms
Heterogeneous nuclear ribonucleoprotein U, hnRNP U, Scaffold attachment factor A, SAF-A, p120, pp120, HNRNPU, HNRPU, SAFA, U211
Gene Name
HNRNPU
UniProt
Q00839
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This HNRNPU antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 766-800 amino acids from the C-terminal region of human HNRNPU.
Clonality
Polyclonal
Tissue Specificity
Widely expressed.
Applications
WB
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Function
104906221808260319029303223259912598661028622508132417381745542862250881745549353307104906221571156319617346238113391049062215711563104906221961734693533072381133918082603223259911717430617289661190293031902930317174306212423132598661021242313259866102124231316286258068679817455492048739405365286225087509195132417392048739405365106715441100364511909954286225082624433323811339223259912232599117174306
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Observed Molecular Weight
90584 Da
Applications Notes
WB: 1:2000
Subcellular Location
Nucleus. Nucleus matrix. Chromosome. Nucleus speckle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Midbody. Cytoplasm Cell surface. Cytoplasmic granule. Note=Localizes at inactive X chromosome (Xi) regions (PubMed:11003645, PubMed:14608463, PubMed:15563465) Localizes in the nucleus during interphase (PubMed:21242313) . At metaphase, localizes with mitotic spindle microtubules (MTs) (PubMed:21242313) . At anaphase, localizes in the mitotic spindle midzone (PubMed:21242313) . Localizes in spindle MTs proximal to spindle poles in a TPX2- and AURKA-dependent manner (PubMed:21242313) . The Ser- 59 phosphorylated form localizes to centrosomes during prophase and metaphase, to mitotic spindles in anaphase and to the midbody during cytokinesis (PubMed:25986610) . Colocalizes with SMARCA4 in the nucleus (By similarity) . Colocalizes with CBX5 in the nucleus (PubMed:19617346) . Colocalizes with NR3C1 in nuclear speckles (PubMed:9353307) . Localized in cytoplasmic ribonucleoprotein (RNP) granules containing untranslated mRNAs (PubMed:17289661) {ECO:0000250|UniProtKB:Q8VEK3, ECO:0000269|PubMed:11003645, ECO:0000269|PubMed:14608463, ECO:0000269|PubMed:15563465, ECO:0000269|PubMed:17289661, ECO:0000269|PubMed:19617346, ECO:0000269|PubMed:21242313, ECO:0000269|PubMed:25986610, ECO:0000269|PubMed:9353307}
Isotype
Rabbit IgG
Contents
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Curated Selection
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