Anti-HNRNPU Antibody (C-term)

Component of the CRD-mediated complex that promotes MYC mRNA stabilization. Binds to pre-mRNA. Has high affinity for scaffold-attached region (SAR) DNA. Binds to double- and single- stranded DNA and RNA. Plays a role in the circadian regulation of the core clock component ARNTL/BMAL1 transcription (By similarity) .

This HNRNPU antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 766-800 amino acids from the C-terminal region of human HNRNPU.

104906221808260319029303223259912598661028622508132417381745542862250881745549353307104906221571156319617346238113391049062215711563104906221961734693533072381133918082603223259911717430617289661190293031902930317174306212423132598661021242313259866102124231316286258068679817455492048739405365286225087509195132417392048739405365106715441100364511909954286225082624433323811339223259912232599117174306

Nucleus. Nucleus matrix. Chromosome. Nucleus speckle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Midbody. Cytoplasm Cell surface. Cytoplasmic granule. Note=Localizes at inactive X chromosome (Xi) regions (PubMed:11003645, PubMed:14608463, PubMed:15563465) Localizes in the nucleus during interphase (PubMed:21242313) . At metaphase, localizes with mitotic spindle microtubules (MTs) (PubMed:21242313) . At anaphase, localizes in the mitotic spindle midzone (PubMed:21242313) . Localizes in spindle MTs proximal to spindle poles in a TPX2- and AURKA-dependent manner (PubMed:21242313) . The Ser- 59 phosphorylated form localizes to centrosomes during prophase and metaphase, to mitotic spindles in anaphase and to the midbody during cytokinesis (PubMed:25986610) . Colocalizes with SMARCA4 in the nucleus (By similarity) . Colocalizes with CBX5 in the nucleus (PubMed:19617346) . Colocalizes with NR3C1 in nuclear speckles (PubMed:9353307) . Localized in cytoplasmic ribonucleoprotein (RNP) granules containing untranslated mRNAs (PubMed:17289661) {ECO:0000250|UniProtKB:Q8VEK3, ECO:0000269|PubMed:11003645, ECO:0000269|PubMed:14608463, ECO:0000269|PubMed:15563465, ECO:0000269|PubMed:17289661, ECO:0000269|PubMed:19617346, ECO:0000269|PubMed:21242313, ECO:0000269|PubMed:25986610, ECO:0000269|PubMed:9353307}