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Anti-MBD2/MBD3 Antibody (Monoclonal, ABM14A8)

Boster Bio Anti-MBD2/MBD3 Antibody (Monoclonal, ABM14A8) (Catalog# M02571) . Tested in IHC, FACS, WB application (s) . This antibody reacts with Human.

Product Specifications

Synonyms

Methyl-CpG-binding domain protein 3; Methyl-CpG-binding protein MBD3; MBD3

Gene Name

MBD3

UniProt

O95983

Host

Mouse

Reactivity

Human

Immunogen

A partial length recombinant MBD3 protein (amino acids 1-290)

Clonality

Monoclonal

Clone

Clone: ABM14A8

Applications

IHC, FACS, WB

Field of Research

2339, Epigenetics and Nuclear Signaling

Purification

Protein G Chromatography

Concentration

0.5-1mg/mL, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Function

Acts as transcriptional repressor and plays a role in gene silencing. Does not bind to DNA by itself (PubMed:12124384) . Binds to DNA with a preference for sites containing methylated CpG dinucleotides (in vitro) . Binds to a lesser degree DNA containing unmethylated CpG dinucleotides (PubMed:24307175) . Recruits histone deacetylases and DNA methyltransferases. .

Storage Conditions

Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Observed Molecular Weight

32844 MW

Gene Name Synonym

Methyl-CpG-binding domain protein 3

Subcellular Location

Nucleus. Chromosome. Nuclear, in discrete foci. Detected on chromatin, at promoter regions of active genes.

Protein Name

Methyl-CpG-binding domain protein 3

Isotype

IgG1 Kappa

Contents

100 μ g in 200 μ l PBS containing 0.05% BSA and 0.05% sodium azide.

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