UPG-108
UPG-108, a peptide compound, is a non-competitive allosteric modulator of Urotensin II receptors (UTR) . UPG-108 significantly enhances the efficacy of UTR agonists but reduces the potency of UTR agonists. UPG-111 efficiently induces calcium release and does not cause contraction of rat aortic rings without endothelial denudation. UPG-111 can be used to study various diseases related to the angiotensinergic system[1].
Product Specifications
CAS Number
[3090686-88-4]
UNSPSC
12352209
Target
Urotensin Receptor
Related Pathways
GPCR/G Protein
Field of Research
Cancer; Metabolic Disease; Inflammation/Immunology; Cardiovascular Disease
Smiles
O=C([C@@H](NC([C@H](C(C)(SSC[C@H](NC([C@@H](NC([C@@H](NC1=O)CCCN)=O)CC2=CC=C(C=C2)O)=O)C(N[C@H](C(O)=O)C(C)C)=O)C)NC([C@H](CC(O)=O)NC([C@H]3N(CCC3)C([C@H]([C@H](O)C)NC([C@@H](N)CCC(N)=O)=O)=O)=O)=O)=O)CC4=CC=CC=C4)N[C@@H]1CC5=CNC6=CC=CC=C56
Molecular Formula
C65H88N14O17S2
Molecular Weight
1401.61
References & Citations
[1]Merlino F, et al. Expanding Structure-Activity Relationships of Human Urotensin II Peptide Analogues: A Proposed Key Role of the N-Terminal Region for Novel Urotensin II Receptor Modulators. J Med Chem. 2024 Aug 22;67 (16) :13879-13890.
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P11258/
Scientific Category
Peptides
Clinical Information
No Development Reported
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
GTR15156570 1 Vial
Lentiviral mouse Cdyl2 shRNA (UAS) - Lentiviral mouse Cdyl2 shRNA (UAS) (100)
Ask
View Details ![Rabbit Monoclonal CXADR Antibody (001) [DyLight 550]](https://cdn.genprice.uk/genprice/genprice5.png)
MBS1024430-01 0.02 mg (E-Coli)
Recombinant Escherichia coli Uncharacterized protein yehD (yehD)
Ask
View Details MBS1024430-02 0.1 mg (E-Coli)
Recombinant Escherichia coli Uncharacterized protein yehD (yehD)
Ask
View Details MBS1024430-03 0.02 mg (Yeast)
Recombinant Escherichia coli Uncharacterized protein yehD (yehD)
Ask
View Details