Anti-cGAS Antibody
Boster Bio Anti-cGAS Antibody catalog # A31676-2. Tested in WB, IHC, ICC/IF, ELISA. This antibody reacts with Human, Mouse.
Product Specifications
Background
CGAS (cyclic GMP-AMP synthase) is a cytosolic DNA sensor that serves to mount an immune response against the invasion of microbial pathogens such as viruses. cGAS normally resides as an inactive protein in the cell. Upon binding to DNA, cGAS undergoes a conformational change to an active state and produces the second messenger cyclic GMP-AMP (cGAMP) from ATP and GTP, which is subsequently detected by the cyclic-dinucleotide sensor STING, an ~40 kDa dimeric transmembrane protein at the endoplasmic reticulum (ER) . cGAS not only is found in the cytosol but has a multifaceted cellular distribution that involves localization at the cell membrane and in the nucleus (PMID: 32424334) . The calculated molecular weight of cGAS is 58 kDa. With post-translational modification, the MW of cGAS will be migrated to 70 kDa.
Gene Name
CGAS
UniProt
Q8C6L5
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
E.coli-derived human cGAS recombinant protein (Position: A352-F504) .
Clonality
Polyclonal
Applications
WB, IHC, ICC/IF, ELISA
Purification
Immunogen affinity purified.
Concentration
500 μg/mL
Form
Liquid
Storage Conditions
12 months from date of receipt, -20°C as supplied. 6 months 2 to 8°C after reconstitution. Avoid repeated freezing and thawing.
Contents
500 μg/mL antibody with PBS,0.02% NaN3, 1 mg BSA and 50% glycerol.
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