Human a-Synuclein Conjugated to Biotin

<strong>Human a-Synuclein Conjugated to Biotin</strong>_x000D_ <strong>Catalog number:</strong> B2011330_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 200 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> 1 mg/mL_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -80 °C_x000D_ <strong>Keywords:</strong> Human recombinant a-Synuclein (1-140), Biotin labeled_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Ray S, Singh N, Kumar R, Patel K, Pandey S, Datta D, Mahato J, Panigrahi R, Navalkar A, Mehra S, Gadhe L, Chatterjee D, Sawner AS, Maiti S, Bhatia S, Gerez JA, Chowdhury A, Kumar A, Padinhateeri R, Riek R, Krishnamoorthy G, Maji SK. α-Synuclein aggregation nucleates through liquid-liquid phase separation Nat Chem. 2020 Aug;12(8):705-716._x000D_ 2: Schweighauser M, Shi Y, Tarutani A, Kametani F, Murzin AG, Ghetti B, Matsubara T, Tomita T, Ando T, Hasegawa K, Murayama S, Yoshida M, Hasegawa M, Scheres SHW, Goedert M. Structures of α-synuclein filaments from multiple system atrophy Nature. 2020 Sep;585(7825):464-469._x000D_ 3: Sulzer D, Edwards RH. The physiological role of α-synuclein and its relationship to Parkinson's Disease J Neurochem. 2019 Sep;150(5):475-486._x000D_ 4: Lau A, So RWL, Lau HHC, Sang JC, Ruiz-Riquelme A, Fleck SC, Stuart E, Menon S, Visanji NP, Meisl G, Faidi R, Marano MM, Schmitt-Ulms C, Wang Z, Fraser PE, Tandon A, Hyman BT, Wille H, Ingelsson M, Klenerman D, Watts JC. α-Synuclein strains target distinct brain regions and cell types Nat Neurosci. 2020 Jan;23(1):21-31._x000D_ 5: Siegert A, Rankovic M, Favretto F, Ukmar-Godec T, Strohäker T, Becker S, Zweckstetter M. Interplay between tau and α-synuclein liquid-liquid phase separation Protein Sci. 2021 Jul;30(7):1326-1336._x000D_ 6: Masuda-Suzukake M, Nonaka T, Hosokawa M, Oikawa T, Arai T, Akiyama H, Mann DM, Hasegawa M. Prion-like spreading of pathological α-synuclein in brain Brain. 2013 Apr;136(Pt 4):1128-38._x000D_ 7: Bartels T, Choi JG, Selkoe DJ. α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation Nature. 2011 Aug 14;477(7362):107-10._x000D_ 8: Kuebler L, Buss S, Leonov A, Ryazanov S, Schmidt F, Maurer A, Weckbecker D, Landau AM, Lillethorup TP, Bleher D, Saw RS, Pichler BJ, Griesinger C, Giese A, Herfert K. [(11)C]MODAG-001-towards a PET tracer targeting α-synuclein aggregates Eur J Nucl Med Mol Imaging. 2021 Jun;48(6):1759-1772._x000D_ 9: Bousset L, Pieri L, Ruiz-Arlandis G, Gath J, Jensen PH, Habenstein B, Madiona K, Olieric V, Böckmann A, Meier BH, Melki R. Structural and functional characterization of two alpha-synuclein strains Nat Commun. 2013;4:2575._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/20798282">10: Burré J, Sharma M, Tsetsenis T, Buchman V, Etherton MR, Südhof TC. Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro Science. 2010 Sep 24;329(5999):1663-7. </a>_x000D_ _x000D_ <strong>Products Related to Human a-Synuclein Conjugated to Biotin can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>