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Anti-Trefoil factor 3 TFF3 Antibody

Boster Bio Anti-Trefoil factor 3 TFF3 Antibody (Catalog # A01738) . Tested in ELISA, WB, IHC-P, ICC, IF applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing. Trefoil peptides contain three intrachain disulfide bonds, forming the trefoil motif, or P-domain and clustered in human chromosome 21q22.3. Trefoil Factor 3 (TFF3) is one of three trefoil peptides secreted by epithelial cells that line mucus membranes in the large and small intestines and lower respiratory tract. TFF3 is mainly active as a disulfide-linked homodimer and may have a role in promoting cell migration in healing processes. It is involved in the maintenance and repair of the intestinal mucosa.

Synonyms

ITF, P1B, TFI, ITF, Trefoil factor 3, Intestinal trefoil factor, hITF

Gene Name

TFF3

UniProt

Q07654

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

TFF3 antibody is predicted to not cross-react with other TFF family members.

Immunogen

TFF3 antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human TFF3. The immunogen is located within the last 50 amino acids of TFF3.

Clonality

Polyclonal

Tissue Specificity

Expressed in goblet cells of the intestines and colon (at protein level) . Expressed by goblet cells of small and large intestinal epithelia and also by the uterus. Also expressed in the hypothalamus where it is detected in paraventricular, periventricular and supraoptic nuclei (at protein level) .

Applications

ELISA, WB, IHC-P, ICC, IF

Field of Research

Homeostasis

Purification

TFF3 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen) .

Storage Conditions

TFF3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Observed Molecular Weight

10181 MW

Gene Name Synonym

Trefoil factor 3 (intestinal)

Subcellular Location

Secreted, extracellular space, extracellular matrix

Prediction Reactivity

Bovine, Pig

Protein Name

Trefoil factor 3 (intestinal)

Isotype

IgG

Contents

TFF3 Antibody is supplied in PBS containing 0.02% sodium azide.

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