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Anti-SREBF2 Antibody

Boster Bio Anti-SREBF2 Antibody (Catalog # A01678) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse.

Product Specifications

Background

The sterol regulatory element binding transcription factor 2 (SREBF2) is a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis (1,2) . The related protein SREBF1 also binds SRE1 and activates transcription in an additive fashion to SREBF2 (2) . SREBF2 has been more closely associated with cholesterol synthesis and accumulation, while the SREBF1 proteins are important in the regulation of genes involved in lipid metabolism (3) .

Synonyms

SREBP2, bHLHd2, SREBP-2, BHLHD2, SREBP2, Sterol regulatory element-binding protein 2, Class D basic helix-loop-helix protein 2

Gene Name

SREBF2

UniProt

Q12772

Host

Rabbit

Reactivity

Human, Mouse

Cross Reactivity

SREBF2 antibody is human and mouse reactive. At least three isoforms of SREBF2 are known to exist. SREBF2 antibody is predicted not to cross-react with SREBF1.

Immunogen

SREBF2 antibody was raised against a 15 amino acid peptide near the center of human SREBF2. The immunogen is located within amino acids 440 - 490 of SREBF2.

Clonality

Polyclonal

Tissue Specificity

Ubiquitously expressed in adult and fetal tissues.

Applications

ELISA, WB, IHC-P, IF

Field of Research

Obesity

Purification

SREBF2 antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway (By similarity) . Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes. .

Storage Conditions

SREBF2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Observed Molecular Weight

123688 MW

Gene Name Synonym

Sterol regulatory element binding transcription factor 2

Subcellular Location

Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. Moves from the endoplasmic reticulum to the Golgi in the absence of sterols.

Prediction Reactivity

Rat

Protein Name

Sterol regulatory element binding transcription factor 2

Isotype

IgG

Contents

SREBF2 antibody is supplied in PBS containing 0.02% sodium azide.

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