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Anti-IL1RN Antibody (C-term)

Boster Bio Anti-IL1RN Antibody (C-term) (Catalog # A00651) . Tested in WB, IF, Flow Cytometry application (s) . This antibody reacts with Human.

Product Specifications

Background

The protein is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. A polymorphism of its gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer.

Synonyms

Interleukin-1 receptor antagonist protein, IL-1RN, IL-1ra, IRAP, ICIL-1RA, IL1 inhibitor, Anakinra, IL1RN, IL1F3, IL1RA

Gene Name

IL1RN

UniProt

P18510

Host

Rabbit

Reactivity

Human

Immunogen

This IL1RN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 147-177 amino acids from the C-terminal region of human IL1RN.

Clonality

Polyclonal

Tissue Specificity

The intracellular form of IL1RN is predominantly expressed in epithelial cells

Applications

WB, IF, Flow Cytometry

Field of Research

Cardiovascular, Immunology, Signal Transduction, Cytokines

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Function

Anti-inflammatory antagonist of interleukin-1 family of proinflammatory cytokines such as interleukin-1beta/IL1B and interleukin-1alpha/IL1A. Protects from immune dysregulation and uncontrolled systemic inflammation triggered by IL1 for a range of innate stimulatory agents such as pathogens.

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

20055 Da

Subcellular Location

[Isoform 1]: Secreted [Isoform 3]: Cytoplasm.

Isotype

Rabbit IgG

Contents

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

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